Herantis Pharma announces initiation of Phase 2 study for Lymfactin gene therapy in secondary lymphedema

Herantis Pharma Plc ("Herantis") announced today the initiation of the Phase 2 clinical study AdeLE (Adenoviral gene therapy for the treatment of LE), which will evaluate the efficacy of Lymfactin® gene therapy in the treatment of secondary lymphedema (LE). The AdeLE study is a multicentre, randomized, double-blind, placebo-controlled study that intends to recruit 40 patients with breast cancer associated LE.  The main goal is to analyse the therapeutic effect of Lymfactin® over placebo on improving the quality-of-life of patients, as well as reducing the swelling and other symptoms associated with the disease. Lymfactin is an adenovirus type 5-based gene therapy expressing human growth factor VEGF-C directly in the damaged tissue to promote the growth and repair of lymphatic vessels and restore the lymphatic network.

"The robust Phase 1 data, confirming safety and tolerability of Lymfactin®, favorably positioned us to quickly move into Phase 2 clinical evaluation, which is an important achievement for this program and the company," said Pekka Simula, Herantis' CEO. "Secondary lymphedema remains a disease with a noteworthy and underserved patient population and as a locally administered single dose therapy, Lymfactin® offers great potential to address this significant gap."

"At the moment there is no curative treatment for lymphedema. Lymfactin® stands out as a unique, easy-to-administer, and hopefully the first curative treatment option in a disease area where current therapies onl