Ryboquin acquires Nanogenic Solutions to advance gene therapy

The Scottish Biotech company Ryboquin, announces the acquisition of Nanogenic Solutions, to form a new product and platform company, Nanogenics Limited. The combined company, Nanogenics, is set to revolutionise gene therapy by pioneering the safe, efficacious and regular dosing of all forms of gene therapy.

The inability to deliver gene therapy into target cells efficiently and with minimal side effects has been holding back the true potential of gene therapy; one of the greatest technical challenges in modern medicine. 

Currently viruses and liposomes are used, which have limited applications, severe side-effects and expensive technical problems. Nanogenics is developing LipTide™, an artificial virus, which acts as a custom-built delivery system that can be modified to target different cell types and deliver different payloads, making the promise of gene therapy one step closer to reality. LipTide™ is a protein based nanoparticle, which mimics natural viruses, but by-passes the many problems of viral delivery. The ability to regularly dose gene therapy payloads with LipTide™ could revolutionise the approach to gene therapy.

Dr Alan Walker, Chief Executive Officer, Nanogenics, says: “I am thrilled we have been able to combine these two businesses. It will offer real hope to those millions of patients living with diseases who have been unable to benefit from the advances in gene therapy because, until now, it has been so difficult to safely deliver the correct gene therapy to the right target. That can now change and we are already working with six major BioTech companies who want to access this exciting platform.”

In addition to working with partners to deliver their gene therapy programmes, Nanogenics is developing its own product pipeline taking advantage of the revolutionary LipTide™ delivery platform. The lead programme, LipTide-ECP102, on which Nanogenics has US and EU patents, dramatically enhances chemotherapy and radiotherapy. A clinical trial is planned at the Christie Hospital Manchester in 2020. Currently LipTide-ECP102 is being scaled up to an industrial batch in collaboration with Strathclyde University.

Paul Murray, Executive Chairman, of the combined company, says: “We have worked hard and convinced investors of the huge potential of LipTide and we plan to grow the company quickly to a stage where we can take it public as soon as that is feasible. It is very rewarding to be involved in the cutting edge of medical science.”

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