New Alzheimer's therapy with brain blood flow discovery? - (ScienceDaily via NewsPoints Desk)

  • Study data published in the journal Nature Neuroscience reveal the cause of decreased blood flow in patients with Alzheimer's disease, ScienceDaily reported Monday.

  • "People probably adapt to the decreased blood flow, so that they don't feel dizzy all of the time, but there's clear evidence that it impacts cognitive function," noted study author Chris Schaffer.

  • In the study, the investigators attempted to induce the development of blood clots in the brains of mice with Alzheimer's disease, finding that the blockages were already present.

  • "What we've done is identify the cellular mechanism that causes reduced brain blood flow in Alzheimer's disease models, which is neutrophils sticking in capillaries," Schaffer said, adding "we've shown that when we block the cellular mechanism, we get an improved blood flow, and associated with that improved blood flow is immediate restoration of cognitive performance."

  • "Now that we know the cellular mechanism…it's a much narrower path to identify the drug or the therapeutic approach to treat it," Schaffer remarked.

  • The research team are currently screening about 20 drugs to determine their potential effects against the identified mechanism.

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