Novel discovery in gene therapy to treat kidney diseases - (The Economic Times via NewsPoints Desk)

  • Researchers writing in the journal Human Gene Therapy describe a novel approach in which three different gene delivery vectors were injected intravenously and directly into the kidneys of mice, as reported in The Economic Times.

  • As the kidney filters out large compounds from the bloodstream, investigators looked at an approach involving small adeno-associated virus vectors, larger adenovirus vectors and lentiviral vectors.

  • To bypass this filtering mechanism, they also tested two different direct injection routes into the kidney and found these to be superior to intravenous injections.

  • However, some of the vectors were able to leak out of the kidney, creating the possibility for off-target tissue effects.

  • The potential for direct injections opens new possibilities for treating kidney diseases with gene therapy, but additional improvements are needed, the authors wrote.

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