Sideromics Announces Formation of Scientific Advisory Board

IRVINE, Calif. /PRNewswire/ -- Sideromics LLC, a pharmaceutical company developing novel antimicrobial compounds to treat and prevent infectious diseases, announced today the formation of a Scientific Advisory Board (SAB) comprised of internationally renowned physicians and scientists.  The mission of the SAB will be to provide scientific, strategic, and clinical advice on the advancement of their antimicrobial candidates for infectious diseases.

Sideromics' Siderocillin is a first-in-class antibiotic group of compounds employing a completely new and novel antimicrobial approach.  Recent preclinical studies show antimicrobial activity in a broad range of pathogenic microorganisms, many of which are the leading cause of serious infection and often death, posing some of the greatest healthcare challenges on a global basis.  Sideromics is pursuing multiple indications in humans and animal infectious diseases. 

Research and development of antibiotics has declined in recent years and the pipeline for antibiotics today is significantly smaller than in the past.  In 1990, there were 18 major pharmaceutical companies engaged in antibiotics research, today there are a handful.  Given the speed at which microbes have become resistant in recent years, the innovation in antibiotics research has not been successful in addressing this growing problem.

The initial appointments to Sideromics' Scientific Advisory Board include:

David Andes, M.D.  -   Professor Medicine and of Medical Microbiology and Immunology at the University of Wisconsin School of Medicine and Public Health in Madison, WI.  Head of the Division of Infectious Disease and Director of the Infectious Disease Fellowship Program.  The focus of Dr. Andes' research programs involves identification of strategies to combat antimicrobial (especially antifungal) drug resistance.  Study approaches include defining the molecular basis for drug resistance, drug target development, pharmacodynamic investigation, and clinical trial study of resistance epidemiology.  Dr Andes has authored many publications, serves as editor of Antimicrobial Agents and Chemotherapy, and is an editorial board member for a number of other prestigious journals.  He is past president of the International Society of Antimicrobial Pharmacology.   After receiving a bachelor of arts in biology from St. Louis University, Missouri, Dr. Andes completed his medical degree at the University of Missouri, in Columbia.  His postgraduate training included a residency in internal medicine, chief residency, and clinical fellowship in infectious disease at the University of Wisconsin, Madison.  He has research training in antimicrobial pharmacodynamics, molecular biology, and molecular mycology.  A principal investigator, co-investigator, and collaborator on a number of research projects on infectious diseases and their treatment, Dr. Andes' publications include co-authoring book chapters, abstracts, and articles in such journals as Antimicrobial Agents and Chemotherapy, Current Opinion in Infectious Disease, and Clinical Infectious Diseases.  He serves on the Editorial Board on Antimicrobial Agents and Chemotherapy and as an ad hoc reviewer for many journals including Clinical Pharmacokinetics, Clinical Microbiology and Infection, Mayo Clinic Proceedings, Medical Mycology, and Clinical Infectious Diseases. Dr. Andes has been an invited lecturer at grand rounds, and local and regional medical education seminars and has made numerous presentations at national and international symposia and conferences.   Honored for both his academic and research contributions to medicine, Dr. Andes is active on hospital and research committees as well as in professional medical associations. He is treasurer of the International Society of Anti-infective Pharmacology. His professional affiliations also include the International Society of Antimicrobial Pharmacology, American Society of Microbiology, American College of Physicians, and European Society of Clinical Microbiology and Infectious Diseases.

David S. Perlin, PhD  -  Executive Director of the Rutgers-New Jersey Medical School's Public Health Research Institute (PHRI), a 73-year-old specialized center for global infectious diseases research.  He is also Director of the new Rutgers Regional Biocontainment Laboratory, one of thirteen NIH-designated national centers, and a Professor of Microbiology and Molecular Genetics. Dr. Perlin helped establish PHRI as a leading center for tuberculosis and opportunistic infections research.  He has published more than 215 papers and book chapters and has co-authored two books. His laboratory is supported by grants from the NIH, pharma and biotech sectors. He is on the editorial board of several scientific journals and serves on the Board of Directors of the Aaron Diamond AIDS Research Center, and Scientific/Medical Advisory Boards for the CLSI, LIFE, pharma and biotech companies, and PinnacleCare.  Dr. Perlin earned an AB degree from Brandeis University in 1976 and a Ph.D. from Cornell University in 1980.  He pursued postdoctoral studies at the Yale University School of Medicine and the University of Rochester School of Medicine and Dentistry. Dr. Perlin joined PHRI in 1985; he was named Scientific Director in 1992, President in 2005, and Director of the new UMDNJ Center in 2006.  He was appointed Professor of Microbiology and Molecular Genetics in 2003 and Executive Director of PHRI and the Rutgers Regional Biocontainment Laboratory in 2010.  Dr. Perlin was named a Fellow of the New York Academy of Sciences in 2005, and a Visiting Professor at the University of Manchester, UK in 2009.

Jeffrey Parker Henderson, M.D., PhD   -   Assistant Professor Departments of Internal Medicine, Infectious Disease, Molecular Microbiology and Center for Women's Infectious Diseases (cWIDR) at the Washington University School of Medicine, in St. Louis, MO.  Dr. Henderson holds leadership roles with the Biochemistry Program and Molecular Microbiology and Microbial Pathogenesis Programs.  His research area of interest includes pathophysiology of enteric Gram negative infections with a special focus on pathogenic interactions with transition metals.  Dr. Henderson holds board certifications in Infectious Disease and Internal Medicine. He received a bachelor of science, with honors, in Chemistry from the University of Wisconsin, his medical degree and a PhD in Molecular Biophysics from the Washington University School of Medicine, St. Louis, MO.  His postgraduate training included Internal Medicine residency and Infectious Diseases fellowship at Barnes-Jewish Hospital/Washington University. He is an NIH principal investigator, co-investigator, and collaborator on multiple infectious diseases research projects involving translation between basic and clinical research. He has published over forty peer-reviewed studies and served as a reviewer for multiple journals including the Proceedings of the National Academy of Sciences, U.S.A., PLoS Pathogens, ACS Infectious Diseases, Infection and Immunity, and Journal of Bacteriology.  Dr. Henderson has been an invited lecturer at the National Institutes of Health, Gordon Research Conferences, and medical grand rounds. His professional affiliations include the Infectious Diseases Society of America, American Society for Microbiology, and the American Society for Biochemistry and Molecular Biology.

Natan Keller, M.D., PhD - Director of the Clinical Microbiology Department at the Chaim Sheba Medical Center, Tel Hashomer, Israel.  He also serves as the chairperson of the Israeli Society for Infectious Disease and has held this position since 2012.  Dr. Keller has served in the Israeli military and received his Doctor of Medicine degree from Hebrew University in Jerusalem.  Dr. Keller holds an executive MBA degree and a PhD in medical microbiology.  He continues to be a lecturer and associate professor in medical epidemiology at the Ariel University Center of Samaria, Ariel, Israel.    Dr. Keller's primary focus in research is microbiology and has presented at scientific meetings around the world.  Dr. Keller has co-authored and published over 100 articles.  Dr. Keller's professional affiliations include the American Society of Microbiology, the Israel Society of Infectious Disease, the Israel Medical Association, and the Immuno Compromised Society.

Dr. Daniel Perl, a co-founder of Sideromics, said "I am excited about working with the distinguished and experienced scientists on our Scientific Advisory Board and look forward to their help in developing our new antimicrobial compounds and bringing them to the bedside." 

About Sideromics

Sideromics is a pharmaceutical company developing novel compounds and methods to treat or prevent diseases and disorders caused by pathogenic microorganisms, such as bacteria, fungi, and parasites.   Sideromics has developed a pipeline of products with possible indications in humans and domestic animals, as well as for use in food-animal growth & processing.  Sideromics' pipeline of products range from early proof-of-concept through advance stages of development.  Current and pending patents and IP cover a broad range of applications in the U.S. and on a global basis. 


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