Regeneron and Sanofi's IL-6R antibody Kevzara was recently approved by the FDA for the treatment of moderate-to-severe rheumatoid arthritis patients who have had an inadequate response or intolerance to one or more disease modifying anti-rheumatic drugs (DMARDs). Kevzara will be priced (in terms of wholesale acquisition cost or WAC) approximately 30 percent less than the TNF-inhibitors Humira and Enbrel but will compete more directly, at least initially, with Roche's marketed IL-6R antibody Actemra, say key opinion leaders.
To ascertain how this competitive dynamic may play out, with are snap-polling US rheumatologists with the following questions…
Kevzara (sarilumab) has been approved by the FDA for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease modifying anti-rheumatic drugs (DMARDs), such as methotrexate (MTX). Kevzara is a human monoclonal antibody that binds to the interleukin-6 receptor (IL-6R), and has been shown to inhibit IL-6R mediated signalling.
How useful is it to have an additional therapy available for the treatment of this condition?
Key opinion leaders we have interviewed view the efficacy of Kevzara (sarilumab) as being very similar to Actemra (tocilizumab). Actemra can be administered intravenously every four weeks or via subcutaneous injection every week. Kevzara is administered by subcutaneous injection every two weeks. Does this provide Kevzara a meaningful competitive advantage?
Very significant advantage
Based on your experience with Actemra (tocilizumab), how satisfied are you with this product?
Not satisfied – I don't use
Eliminating cost as a factor, do you think you would be compelled to use Kevzara (sarilumab) as an alternative therapy to Actemra (tocilizumab)?
In what line of therapy would you expect to use Kevzara (sarilumab) most frequently during its first few years on the market?
First-line – i.e. after methotrexate
After two prior therapies
After three prior therapies
After four prior therapies
After five prior therapies
I don't anticipate using Kevzara
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