following a full submission assessed under the ultra-orphan medicine process:
crizotinib (Xalkori®) is accepted for use within NHSScotland.
Indication under review: treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC).
In a small, single arm, open-label, phase I study of patients with advanced ROS1-positive NSCLC, treatment with crizotinib resulted in an objective response in 70% of patients.
This SMC advice takes account of the benefits of a Patient Access Scheme (PAS) that improves the cost-effectiveness of crizotinib. This advice is contingent upon the continuing availability of the PAS in NHSScotland or a list price that is equivalent or lower.
This advice takes account of views from a Patient and Clinician Engagement (PACE) meeting.
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