Formerly comprising only Roche's Xolair (first approved by the FDA in 2003), the US market for biologic therapies indicated for the treatment of moderate-to-severe asthma has undergone considerable change in recent years; thanks to the approval of GlaxoSmithKline's Nucala, Teva's Cinqair and AstraZeneca's Fasenra.
Further evolution is expected with Sanofi and Regeneron Pharmaceuticals' dupilumab (already marketed as Dupixent for the treatment of atopic dermatitis) awaiting approval by the FDA, with a decision expected next month at the latest.
Ahead of this key market catalyst, and six months after our last physician snap-poll in this field, we are taking the pulse of US-based pulmonologists to see how the market for biologic therapies is evolving and whether one of the recent launches is standing out ahead of its rivals. Competition among the new class of anti-IL-5 antibodies, particularly between Nucala and Fasenra, is intensifying.
Approximately what percentage of the moderate-to-severe asthma patients you currently manage is treated with a biologic therapy?
Using a five-point scale (1 = none / 5 = very significant increase), what impact has the availability of anti-IL-5 antibody products - Nucala (mepolizumab), Cinqair (reslizumab) and Fasenra (benralizumab) - had on your overall use of biologic therapies of the management of moderate-to-severe asthma?
Based on your experience with the anti-IL-5 class and their respective clinical/dosing profiles, do you consider one of the products to be superior to the others?
No - too early to tell
No - I’m confident they are comparable
Yes - Nucala (mepolizumab)
Yes - Cinqair (reslizumab)
Yes - Fasenra (benralizumab)
What percentage of moderate-to-severe asthma patients do you expect to treat with a biologic therapy in three years' time?
Using a five-point scale (1=none - 5= very significant), please rate your awareness of dupilumab as a potential future treatment option for moderate-to-severe asthma
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