Approved earlier this month by the FDA with a broad label for relapsing forms of multiple sclerosis, Novartis' oral drug Mayzent also became the first treatment specifically authorised for patients with active secondary progressive disease. Analysts were quick to highlight the opportunity cited by Novartis to target patients with relapsing remitting MS who are 'in transition' to secondary progressive disease.
To get a better understanding of how Mayzent may impact the treatment landscape we are snap-polling US neurologists…
Q. Mayzent (siponimod) has been approved by the FDA for the treatment of relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing remitting MS and active secondary progressive MS in adults (full label here).
Approval was based on data from the Phase III EXPAND trial, showing that Mayzent significantly reduced the risk of three-month confirmed disability progression in patients with active secondary progressive MS by 21 percent versus placebo. In the study, the drug also reduced the annualised relapse rate by 55 percent.
Mayzent will have a list price of $88,000 per year. Most patients will not require a first dose observation, unless they have certain pre-existing cardiac conditions.
How disruptive an effect do you think Mayzent will have on the MS treatment landscape?
Q. How compelling a treatment option do you think Mayzent is for relapsing remitting patients who are 'in transition' to secondary progressive MS?
Q. How compelling a treatment option do you think Mayzent is for patients who have active secondary progressive MS?
Q. What impact do you think the availability of Mayzent will have on increasing diagnosis rates for secondary progressive MS?
Very significant impact
Q. Which marketed MS therapies do you think Mayzent will most frequently be prescribed at the expense of?
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