Takeda recently unveiled data showing Entyvio was superior to AbbVie's Humira at achieving clinical remission in moderate-to-severe ulcerative colitis patients at 52 weeks.
These results could see Entyvio used more frequently and as an earlier line of therapy, a leading expert told FirstWord, though Johnson & Johnson and Merck & Co.'s Remicade is the most frequently prescribed anti-TNF for UC, rather than Humira.
To get a better understanding of how these results could change prescribing patterns, we are snap-polling US and EU3 (France, Germany and UK) based gastroenterologists with the following questions…
Q. Newly disclosed results from a Phase III study of patients with moderate-to-severe active ulcerative colitis show that Entyvio (vedolizumab) was superior to Humira (adalimumab) at achieving clinical remission at 52 weeks.
31.3 percent of patients given Entyvio achieved the primary endpoint of clinical remission, which was significantly more than 22.5 percent of those on Humira. Data also showed that 39.7 percent of patients in the Entyvio arm exhibited mucosal healing at week 52, versus 27.7 percent of those treated with Humira.
Patients enrolled in the study had previously had an inadequate response or intolerance to corticosteroids, immuno-modulators or a TNF-alpha antagonist other than Humira.
Do these results support first-line positioning of Entyvio in moderate-to-severe ulcerative colitis?
Q. In a real-world setting, how much impact do you expect these data to have on increasing the use of Entyvio as a first-line therapy for moderate-to-severe ulcerative colitis?
Very significant impact
Q. Based on your real-world experience, what is your clinical assessment of Entyvio versus Remicade (infliximab) for the treatment of moderate-to-severe ulcerative colitis?
Entyvio is a superior therapy
Remicade is a superior therapy
They are comparable
Q. In which setting for the treatment of moderate-to-severe ulcerative colitis are you likely to use Entyvio most frequently in the future?
Pre-TNF inhibitor therapy
Post-TNF inhibitor therapy
Q. Is Entyvio suited to a particular cohort of moderate-to-severe ulcerative colitis patients?
Broadly all moderate-to-severe patients
Patients with more moderate disease
Patients with more severe disease
Results and related analysis will shortly be published for FirstWord Pharma PLUS subscribers to read, with the opportunity for non-FirstWord Pharma PLUS subscribers to purchase these findings. To be notified when poll results and analysis become available, please click here.
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