Perinatal Factors Do Not Affect Paediatric Inflammatory Bowel Disease Risk: Presented at ECCO-IBD

By Eric Ramos

VIENNA, Austria -- February 15, 2020 -- Perinatal factors, such as mode of delivery, gestational age, and type of infant feeding do not affect paediatric inflammatory bowel disease risk, according to a study presented here at the 15th Congress of the European Crohn’s and Colitis Organisation - Inflammatory Bowel Diseases (ECCO-IBD).

“This robust, validated population-based study of over 2 million Scottish births utilising administrative health data confidently demonstrates no association between mode of delivery, gestational age, or type of feeding and the development of paediatric inflammatory bowel disease,” reported Christopher Burgess, University of Edinburgh, and the Royal Hospital for Sick Children, Edinburgh, United Kingdom.

The researchers conducted the study due to the continuous increase in cases of paediatric inflammatory bowel disease.

“Given gestation and infancy are sensitive periods for environmental change, we aimed to determine whether perinatal factors contribute to the development of paediatric inflammatory bowel disease,” said Dr. Burgess.

A total of 2,013,851 children born in Scotland between 1981 and 2017 were identified within the Scottish Morbidity Record maternity inpatient dataset. Validation was performed within an entire Scottish health board (16% of the total population) via individual case-note verification.

There were a total of 1,721 cases of paediatric inflammatory bowel disease -- defined as any inpatient ICD coding for Crohn’s disease, ulcerative colitis, or inflammatory bowel disease unclassified until age 16 years.

The researchers found no increased risk of paediatric inflammatory bowel disease among children delivered vaginally versus caesarean section (hazard ratio [HR] = 0.95), among children born prematurely (24-31 weeks gestation, HR = 0.97; 32-36 weeks gestation, HR = 0.96), and among children not exclusively breastfeeding at 6 weeks (formula feeding, HR = 0.97; other/unknown feeding type, HR = 0.90).
The authors noted that genetic-environmental interactions are expected to play a vital role in paediatric inflammatory bowel disease. Further research is warranted.

[Presentation title: Perinatal Factors Do Not Affect Paediatric Inflammatory Bowel Disease Risk: a Scottish Nationwide Cohort Study Using Administrative Health Data 1981-2017. Abstract OP19]

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