Fresh-Faecal Microbiota Transplantation After Antibiotic Therapy Improves Remission Rates in Patients Ulcerative Colitis: Presented at ECCO-IBD

By Eric Ramos

VIENNA, Austria -- February 15, 2020 -- Fresh-faecal microbiota transplantation (FMT) following triple-antibiotic therapy improves clinical response and remission rates in patients ulcerative colitis, according to a study presented here at the 15th Congress of the European Crohn’s and Colitis Organisation - Inflammatory Bowel Diseases (ECCO-IBD).

“Fresh-faecal microbiota transplantation following treatment with amoxicillin, fosfomycin, and metronidazole exhibited reassuring short-term and long-term clinical outcomes,” reported Dai Ishikawa, PhD, Juntendo University, Tokyo, Japan.

For the study, the researchers randomised patients aged 20 years and older with ulcerative colitis and a Lichtiger’s clinical activity index (CAI) of ≥5 or with an endoscopic Mayo score of ≥1 to receive fresh-faecal microbiota transplantation following triple antibiotic therapy (n = 47) or triple antibiotic therapy alone for 2 weeks (n = 32). Patients’ spouses or relatives in the family were selected as donors.

At 4 weeks, clinical response -- defined as a decrease of CAI of ≥3 points -- was achieved by 65.9% patients in the faecal transplant group compared with 56.2% of patients in the antibiotic monotherapy group. Clinical remission was observed in 40.4% of patients in the faecal transplant group compared with 18.7% of patients receiving antibiotics alone.

Maintenance rates -- defined as no exacerbation of CAI and no intensification of treatments among clinical responders -- at 12 months (P = .046) and 24 months (P = .034) were significantly higher in the faecal transplant group. Lower maintenance rates were observed if there was more than an 11-year age gap between patients and donors (P = .003).

Patients matched with sibling donors had significantly higher maintenance rates than parent-child relationship matches (P = .009).

“This is the first report of faecal microbiota transplantation to reveal the importance of matching between donors and patients for long-term maintenance on ulcerative colitis,” stated Dr. Ishikawa.

[Presentation title: Matching Between Donors and Patients in Faecal Microbiota Transplantation Is Important for Long-Term Maintenance on Ulcerative Colitis. Abstract DOP04]

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